Advices

Where are funny channels in the heart?

Where are funny channels in the heart?

The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue.

Why is it called a funny channel?

Funny current (or funny channel, or If) refers to a specific current in the heart. It is called “funny” because it has effects opposite to those of most other heart currents. If is a mixed Na+–K+ inward current activated by hyperpolarization and modulated by the autonomic nervous system.

What triggers the funny current?

‘Funny’ (f) channels are activated by intracellular cyclic adenosine monophosphate (cAMP) concentrations according to a mechanism mediating regulation of heart rate by the autonomic nervous system, as well as by voltage hyperpolarisation.

What does the funny current do?

The “funny” (If) current, originally described in sinoatrial node myocytes as an inward current activated on hyperpolarization to the diastolic range of voltages, has properties suitable for generating repetitive activity and for modulating spontaneous rate.

What does funny current do?

Why is it called the funny bone?

The “funny bone” got its nickname because of that funny feeling you get after you hit it. But your funny bone isn’t actually a bone at all. Running down the inside part of your elbow is a nerve called the ulnar nerve. The ulnar nerve lets your brain know about feelings in your fourth and fifth fingers.

What is the function of funny current?

Is there a funny current in the heart?

The identity between the 2 “pacemaker” currents in the 2 cardiac tissues led to an integrated theory for the origin of cardiac pacemaking in different pacing regions of the heart. A systematic characterization of the funny current followed the reinterpretation of IK2 and its identification with If. 2,25.

What is the role of funny channels in pacemaking?

Their role in cardiac pacemaking naturally make funny channels a target for the development of substances specifically developed for pharmacological control of heart rate, such as the heart rate-reducing agents, potentially useful in the treatment of several cardiac diseases.

What is the function of funny channels?

‘Funny’ (f) channels are activated by intracellular cyclic adenosine monophosphate (cAMP) concentrations according to a mechanism mediating regulation of heart rate by the autonomic nervous system, as well as by voltage hyperpolarisation.

What is funny current in cardiac pacemaker?

First described in the late 1970s in Purkinje fibers and sinoatrial myocytes, the cardiac pacemaker “funny” (I f) current has been extensively characterized and its role in cardiac pacemaking has been investigated.