What is the serum tumor marker for epithelial type of ovarian cancer?

What is the serum tumor marker for epithelial type of ovarian cancer?

At present, CA125 remains the most important biomarker for epithelial ovarian cancer, excluding tumors of mucinous origin.

What is the most common histopathological type of ovarian carcinoma?

HGSCs are by far the most common histologic subtype, accounting for over 50% of all ovarian carcinomas.

What does GATA-3 positive mean?

In univariate analysis, the presence of GATA-3 is a marker of good prognosis and predicted for superior breast cancer-specific survival, relapse-free survival, and overall survival.

Is Endometroid carcinoma curable?

This means the cancer occurs in the cells that develop the glands in the endometrium. Endometrial cancer is highly curable when found early.

What tumor marker is elevated in ovarian cancer?

Cancer Antigen 125 (CA125) and Human Epididymis Protein 4 (HE4) are the most studied ovarian tumor markers. Their diagnostic performance for identification of ovarian cancer are superior to CA19-9, CA72-4, and carcinoembryonic antigen, which are no more recommended for the diagnosis of presumed benign ovarian tumor.

Can immunohistochemical features improve histologic subclassification of endometrioid carcinomas?

Ovarian endometrioid carcinomas (OEC) of low grade have characteristic morphologic features, but high-grade tumors can mimic high-grade serous and undifferentiated carcinomas. We reviewed tumors initially diagnosed as OEC to determine whether a combination of pathologic and immunohistochemical features can improve histologic subclassification.

How common is endometrioid histology in women with ovarian cancer?

Results: Five hundred and thirty-three women with ovarian cancer were included in the study cohort; 98 (18.4%) had endometrioid histology and 435 (81.6%) serous histology. The five-year OS rate for women with endometrioid cancer was 80.6%, and for women with serous ovarian cancer, it was 35.0%.

Is there an IHC algorithm for ovarian carcinoma histotyping?

Our objective was to reclassify the recently assembled Canadian Ovarian Experimental Unified Resource and the Alberta Ovarian Tumor Type cohorts using immunohistochemical (IHC) biomarkers and to develop an IHC algorithm for ovarian carcinoma histotyping.

Is endometrioid cancer more dangerous than serous ovarian cancer?

After adjusting for confounders excluding stage, there was a significantly lower risk of death from endometrioid cancer compared to serous ovarian cancer (hazard ratio [HR] 0.41, 95% CI 0.26 to 0.66). However, the difference was no longer significant after adding tumour stage to the model (HR 0.74, 95% CI 0.45 to 1.24).