What is the mechanism of isoniazid injury?

Chronic INH hepatotoxicity results in the induction of hepatocyte apoptosis, with associated disruption of mitochondrial membrane potential and DNA strand breaks. The most likely biochemical mechanism is that the metabolism of INH produces reactive metabolites that bind and damage cellular macromolecules in the liver.

How does isoniazid cause neurotoxicity?

The increased sensitivity of the dialysis population to isoniazid neurotoxicity is predominantly due to abnormal metabolism of pyridoxine resulting in low serum levels of the active metabolite, pyridoxal phosphate.

Why does isoniazid cause tingling?

Damage to nerves (peripheral neuropathy) may occur with isoniazid and cause numbness and tingling of the hands or feet (parethesia). Other rare side effects related to the nervous system include: Encephalopathy (inflammation of the brain) Optic neuritis (inflammation of the nerve coming from the eye)

Is drug induced peripheral neuropathy reversible?

Drug-Induced Peripheral Neuropathy (DIPN) occurs when a chemical substance causes damage to the peripheral nervous system [1]. DIPN is potentially irreversible, resulting in sensory deficits and paresthesia typically in a glove and stocking type distribution; motor involvement is rare.

Is isoniazid a neurotoxic?

Isoniazid did not cause neurotoxicity at exposures up to 7 days. Hydrazine was found to be the most toxic metabolite with LC50 values of 2.7 mM and 0.3 mM after 7 days of exposure in DRG neurons and N18D3 hybrid neurons, respectively.

What are the adverse effects of isoniazid?

What are the possible side effects of isoniazid?

• sudden weakness or ill feeling, or fever for 3 days or longer;
• pain in your upper stomach (may spread to your back), nausea, loss of appetite;
• dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• vision changes, pain behind your eyes;

What is meaning of peripheral neuropathy?

(peh-RIH-feh-rul noor-AH-puh-thee) A nerve problem that causes pain, numbness, tingling, swelling, or muscle weakness in different parts of the body. It usually begins in the hands or feet and gets worse over time. Peripheral neuropathy may be caused by cancer or cancer treatment, such as chemotherapy.

What drugs cause peripheral neuropathy?

Some medications that may cause peripheral neuropathy are the following: Statin medications used to lower cholesterol: Atorvastatin, Pitavastatin, Lovastatin, Simvastatin, Pravastatin, Fluvastatin, Rosuvastatin Heart or blood pressure medications: Amiodarone, Hydralazine, Perhexiline, Procainamide

What is the best treatment for peripheral neuropathy?

Treating the underlying cause. There are many different causes of peripheral neuropathy,some of which can be treated in different ways.

How to get rid of peripheral neuropathy?

– Exercise. A number of health conditions; exercise is a remedy. – Quit smoking. Smoking is a causative factor to almost every health condition as smoking affects blood circulation. – Vitamins. Some cases of peripheral neuropathy are related to vitamin deficiency. – Essential Oils. – Dietary supplementation. – Healthy diet.

How to recognize the different stages of peripheral neuropathy?

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