What is Hydroxybupropion used for?
Bupropion is an antidepressant approved for the treatment of major depressive disorders. This drug is also used for smoking cessation.
How many chiral centers are in bupropion?
As shown in Figure 1, bupropion has one chiral center and clinically it is administered as racemic mixture.
Is Wellbutrin a Cathinone?
Cathinone is the β-keto analog of amphetamine, and all synthetic cathinones display a β-keto moiety in their structure. Several synthetic cathinones are widely prescribed medications (e.g., bupropion, Wellbutrin®), while others are problematic drugs of abuse (e.g., 4-methylmethcathinone, mephedrone).
Is Bupropion a prodrug?
Bupropion is also an attractive compound from the multistep prodrug standpoint as it serves as a model for the presentation of a double prodrug, containing two potential prodrug functional groups.
What is the difference between SSRI and NDRI?
SNRIs are different from SSRIs as they prevent the reuptake of both serotonin and norepinephrine in the brain. An imbalance of serotonin and norepinephrine is believed to be linked to the occurrence of anxiety disorders and panic disorder.
Is Wellbutrin an SNRI?
Wellbutrin, which is not an SSRI or SNRI, is less likely to affect platelet functions. When used with serotonergic drugs, Effexor and Wellbutrin can increase the risk of serotonin syndrome. Symptoms of serotonin syndrome include an increased heart rate, increased blood pressure, and fever.
Is bupropion the same as buprenorphine?
It can be considered that buprenorphine is a practical and safe medication for the cessation or reduction of methamphetamine withdrawal craving and is better than bupropion. Use of buprenorphine could be considered for the treatment of methamphetamine craving.
Is bupropion a SNRI?
Wellbutrin is the brand name for bupropion, which is neither an SSRI nor an SNRI, but rather an NDRI. Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Aplenzin) is used to treat depression.
What is a good substitute for bupropion?
Is bupropion an NDRI?
These data confirm that bupropion is a dual norepinephrine and dopamine reuptake inhibitor (NDRI) in humans at clinically relevant doses.
What medications are NDRI?
Bupropion (Aplenzin, Wellbutrin,) is the only NDRI sold on the market. Your doctor may prescribe it or add it to your therapy if you haven’t felt better with other treatments. Doctors also prescribe bupropion under a different brand name, Zyban, to help people quit smoking.
What is hydroxybupropion?
Hydroxybupropion is the most potent of the metabolites. It is formed via the “ hydroxylation of the tert-butyl group ” by CYP2B6 and is excreted renally. Cmax vales of hydroxybupropion are 4-7 times that of bupropion, while the exposure to hydroxybupropion is “10 fold” that of bupropion.
What is the CAS number for hydroxybupropion?
[CAS Number 92264-81-8] Hydroxybupropion is a major metabolite of the antidepressant and smoking cessation drug bupropion. Hydroxybupropion is available as reference material (bulk powder and/or solution) and as calibrated, Ready-to-Use, certified reference material (CRM).
What does 6-hydroxybupropion stand for?
Hydroxybupropion (code name BW 306U ), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment, hydroxybupropion is present in plasma…
Where is hydroxybupropion found in the pathway?
All Rights Reserved. Hydroxybupropion is found in the bupropion degradation pathway. Bupropion reacts with NADPH and O2 to produce hydroxybupropion, with NADP+ and H2O as byproducts. HMDB is offered to the public as a freely available resource.