What is GPIb in platelets?

What is GPIb in platelets?

Glycoprotein Ib (GPIb), also known as CD42, is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury. It is deficient in the Bernard–Soulier syndrome.

Is gp1b a platelet?

Glycoprotein Ib–IX–V complex (GPIb–IX–IV) is exclusively expressed in platelets and megakaryocytes, which is responsible for Von Willebrand factor (VWF)-mediated platelet activation and aggregation.

What is the function of vWF?

Von Willebrand factor (VWF) is a large multimeric glycoprotein that performs two critical functions in primary hemostasis: it acts as a bridging molecule at sites of vascular injury for normal platelet adhesion, and under high shear conditions, it promotes platelet aggregation.

Where is gp1b found?

GPIb-IX-V is found on the surface of small cells called platelets, which circulate in blood and are an essential component of blood clots. The complex can attach (bind) to a protein called von Willebrand factor, fitting together like a lock and its key.

What is a thrombocytosis mean?

Thrombocytosis (throm-boe-sie-TOE-sis) is a disorder in which your body produces too many platelets. It’s called reactive thrombocytosis or secondary thrombocytosis when the cause is an underlying condition, such as an infection.

Is VWF a platelet?

von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the second, synthesized by megakaryocytes, circulates in platelets primarily stored in the alpha granules.

How common is Glanzmann’s thrombasthenia?

Glanzmann thrombasthenia is estimated to affect 1 in one million individuals worldwide, but may be more common in certain groups, including those of Romani ethnicity, particularly people within the French Manouche community.

What is beta-2 glycoprotein 1 IgG?

Beta 2 glycoprotein IgG is a type of antibody found in the blood. Beta-2 glycoprotein 1 IgG is an antibody that is linked to the improper clotting of blood.

Which glycoprotein genes are conserved in herpes?

There are several glycoprotein genes conserved in all sequenced herpesviruses. These genes are glycoprotein B (gB), glycoprotein H (gH), glycoprotein M (gM) and glycoprotein L (gL), and also are conserved in HHV-6 and HHV-7.

Where can I find beta-2 glycoprotein I (beta2gpi) in Australia?

1 Department of Immunology, Allergy and Infectious Diseases, University of New South Wales, St. George Hospital, 2 South Street, Kogarah, NSW 2217, Australia. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS).

Is alpha 1-B glycoprotein fragmentation a differential urinary biomarker in steroid-resistant nephrotic syndrome?

an 11-fold upregulated 13.8 kDa fragment of alpha 1-B glycoprotein (A1BG) as a biomarker for steroid-resistant nephrotic syndrome Title: Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome.