What happens to the body with neurofibromatosis type 1?

NF1 can cause curvature of the spine (scoliosis) that may need bracing or surgery. NF1 is also associated with decreased bone mineral density, which increases the risk of weak bones (osteoporosis). Vision problems. Sometimes a tumor develops on the optic nerve (optic glioma), which can affect vision.

What organs are affected by neurofibromatosis type 1?

Neurofibromatosis (NF) is a genetic neurological disorder that can affect the brain, spinal cord, nerves and skin. Tumors, or neurofibromas, grow along the body’s nerves or on or underneath the skin. Scientists have classified NF into two distinct types: neurofibromatosis type 1 (NF1) and NF2.

Is neurofibromatosis type 1 a rare disease?

NF1 is a rare disorder that affects males and females in equal numbers. NF1 affects all races and ethnic groups equally and is estimated to occur in 1 in 2,500 to 3,000 births.

Who is mostly affected by neurofibromatosis type 1?

The incidence of NF1 is approximately one in 3,000 live births and it affects males and females of all races equally. Because neurofibromatosis type 1 is hereditary, the risk of developing the features associated with NF1 may be passed from generation to generation in a family.

What is the difference between NF1 and NF2?

Neurofibromatosis type 2 (NF2) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign) but may cause a range of symptoms. Neurofibromatosis type 1 (NF1) is covered separately because it has different symptoms and causes. It’s also much more common than NF2.

Is neurofibromatosis type 1 an autoimmune disease?

Neurofibromatosis type 1 is a relatively common autosomal dominant disorder. It is well known that NF1 patients have an increased risk of developing a variety of benign and malignant tumors, but its association with autoimmune diseases has been rarely reported (1-3).

How many café-au-lait spots are normal?

Café au lait spots are harmless and normal, with some people having anywhere from one to three spots. But sometimes, these spots can indicate an underlying genetic problem.