What does PGC 1 alpha do?

PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism.

What is PGC 1 alpha gene?

PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors.

Is PGC 1 alpha a transcription factor?

Introduction Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) is an auxiliary transcription activating factor (transcriptional coactivator), and it controls the genes related to energy metabolism.

What stimulates PGC 1a?

Chromatin immunoprecipitation assay showed that the mechanism for this effect involves liver X receptor α (LXRα) coactivation that stimulates PGC-1α binding to the liver X receptor-responsive element (LXRE) in FAS promoter.

What activates PGC 1alpha?

During fasting, the expression of PGC-1α is activated by glucagon and catecholamines via the stimulation of the cAMP pathway and the CREB transcription factor. PGC-1α then coactivates a variety of transcription factors such as hepatic nuclear factor-4α, glucocorticoid receptor, and forkhead box O1 (FOXO1).

What is PGC diabetes?

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM.

What is the function of PGC-1 Alpha?

PGC-1 alpha serves as a co-activator for the liver X receptor (LXR) alpha, known to contribute to the regulation of cellular cholesterol homoeostasis role of LXXLL domain for ligand-dependent and ligand-independent interaction and coactivation of peroxisome proliferator-activated receptor gamma

What is the pathway of PGC-1α activation?

The upstream signaling involved in the activation of PGC-1α are unclear at present, but several pathways have been implicated, such as the calcineurin A and CaMK, p38 MAPK, and AMP-activated protein kinase pathways ( 1, 67, 73 ).

Where is the PGC-1α gene located?

The PGC-1α gene is located on chromosome 5 in mice (chromosome 4 in humans) and encodes a protein containing 797 (mouse) or 798 amino acids (human). PGC-1α has two putative nuclear localization signals and is located in the cell nucleus ( 49 ).

Is PGC-1alpha a target for Metabolic gene activation during exercise?

PGC-1alpha may coordinate activation of metabolic genes in human muscle in response to exercise. Data demonstrate that the multi-hormone response element of the estrogen-related receptor-alpha (ERRalpha) gene is a target for ERRgamma transactivation, which is enhanced by peroxisome proliferator-activated receptor-gamma coactivator-1alpha.