What does CSF1R stand for?

In this context, the colony-stimulating factor 1 (CSF1)/colony-stimulating factor 1 receptor (CSF1R) axis has gained the most attention, and various approaches targeting either the ligands or the receptor are currently in clinical development.

What are the best CSF1R inhibitors for leukemia?

Leukemia: Gleevec, bosutinib, and dasatinib are among the CSF1R inhibitors that are approved by the U.S. Food and Drug Administration (FDA) to take on leukemia or other disorders or cancers of the blood. 4 

How dangerous are CSF1R inhibitors?

The potential danger of CSF1R inhibitors is that they can negatively affect liver, kidney, immune, and cardiac function, especially if taken for longer periods of time. Here’s a quick breakdown of more adverse side-effects seen with this class of medication: 5 

Is CSF1R related adult-onset leukoencephalopathy (ALSP) inherited?

CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is inherited in an autosomal dominantmanner. Risk to Family Members Parents of a proband Most individuals with CSF1R-related ALSP have an affected parent, although de novomutation can occur [Rademakers et al 2011, Kinoshita et al 2012, Stabile et al 2016].

Colony-stimulating factor 1 (CSF1) receptor (CSF1R) has two ligands, CSF1 and IL-34. It has been shown that signals mediated by CSF1R are involved in microglial differentiation and proliferation.

Are there any CSF1R inhibitors in clinical development?

Only two clinical-stage programs are currently targeting CSF1. No molecules targeting IL-34, the second-known ligand for CSF1R, are in clinical development thus far. We use “CSF1R inhibitor” as a general term for both receptor- and ligand-targeting compounds.

Are there any molecules that target CSF1R?

No molecules targeting IL-34, the second-known ligand for CSF1R, are in clinical development thus far. We use “CSF1R inhibitor” as a general term for both receptor- and ligand-targeting compounds.

What is the role of CSF1R in microglial differentiation?

Colony-stimulating factor 1 (CSF1) receptor (CSF1R) has two ligands, CSF1 and IL-34. It has been shown that signals mediated by CSF1R are involved in microglial differentiation and proliferation. Recently, an increasing number of studies have examined microglial functions by depleting microglia using CSF1R inhibitors.