What does c-Myc protein do?

What does c-Myc protein do?

C-Myc protein is a member of a family of proteins that regulate cell proliferation and apoptosis. The ability of c-myc to regulate apoptotic cell death results from the coordinated activation of c-Myc and several protein partners (such as Max) that facilitate DNA binding and activate transcription.

What is Myc bind?

The c-myc gene product, Myc, is a transcription factor that can either activate or repress gene expression. Activation occurs through dimerization with the partner protein Max, and binding to the consensus DNA sequence CACGTG (E-box).

Does the MYC protein bind to DNA?

Full-length c-Myc alone cannot bind DNA. However, a truncated c-Myc protein comprising the basic, helix-loop-helix, and leucine zipper regions can bind specifically to DNA bearing the sequence GGGCAC(G/A)TGCCC.

What does c-Myc gene mean?

The Myc family was first established after discovery of homology between an oncogene carried by the Avian virus, Myelocytomatosis (v-myc; P10395) and a human gene over-expressed in various cancers, cellular Myc (c-Myc).

What is the difference between C-Myc and N myc?

c-Myc is broadly overexpressed in both blood-borne and solid tumors. N-myc is most frequently overexpressed in solid cancers of neural origin, such as neuroblastoma and glioma.

Is C-MYC a tumor suppressor gene?

Abstract. The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes.

What is C-MYC promoter?

The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy.

How many amino acids are present in the MYC protein?

The gene encodes for a major 439 amino acid, 64 kDa c-Myc protein.

Does c-Myc cause apoptosis?

c-MYC represses some of the survival pathways associated with death receptor and DISC activation, and this can promote apoptosis. Death receptor signaling can activate the nuclear factor-κB (NF-κB) transcription factor, which suppresses receptor-induced apoptosis.