Is trabectedin a vesicant?
Optimizing safety in outpatient administration of trabectedin, a novel anticancer vesicant drug via continuous intravenous infusion.
What does docetaxel extravasation cause?
Docetaxel is an antineoplastic agent widely used in the treatment of numerous solid tumors, including breast, lung, ovarian and prostate carcinomas (3). The well-known adverse effects of docetaxel include neutropenia, fluid retention, neuropathy, hypersensitivity reaction, alopecia, mucositis or nail changes (4).
How is doxorubicin extravasation treated?
- Dexrazoxane. Dexrazoxane is an iron chelator that prevents anthracycline-iron complexes and free radical formation causing oxidative damage.
- Dimethyl sulfoxide (DMSO)
- As L-asparaginase is a non-irritant, it is fairly benign.
How do you treat vincristine extravasation?
Generally cold compresses are recommended for extravasation of all irritant and vesicant drugs except vinca alkaloids (vincristine, vinblastine, vinorelbine), epipodophyllotoxins (etoposide), oxaliplatin, and vasopressors, as cold worsens tissue ulceration caused by these drugs.
What is the antidote for docetaxel extravasation?
Use the antidote specific to the agent. Apply dry cold compresses for about 20–30 min, then as needed. *No recommended antidote. †Recommended antidote: dexrazoxane or dimethyl sulfoxide (DMSO).
What is it called when an IV backs up?
Extravasation is the leakage of intravenously (IV) infused, and potentially damaging, medications into the extravascular tissue around the site of infusion.
What is the antidote for DAUNOrubicin?
3.3. 2 Antidotes and Treatments for Extravasation
|Dactinomycin DAUNOmycin (DAUNOrubicin) DOXOrubicin Epirubicin Mitoxantrone||COLD|
|VinBLAStine VinCRIStine Vinorelbine||WARM|
What is fluid extravasation?
Extravasation is the leakage of a fluid out of its container into the surrounding area, especially blood or blood cells from vessels. In the case of inflammation, it refers to the movement of white blood cells from the capillaries to the tissues surrounding them (leukocyte extravasation, also known as diapedesis).
What is the first treatment for extravasation?
At the first sign of extravasation, the following steps are recommended: (1) stop administration of IV fluids immediately, (2) disconnect the IV tube from the cannula, (3) aspirate any residual drug from the cannula, (4) administer a drug-specific antidote, and (5) notify the physician (Fig. 1).