How do you dilute diazepam?

However, if in some circumstances it is necessary to administer diazepam as an infusion, it is recommended that it be diluted in dextrose 5% in water, normal saline, Ringer’s injection or lactated Ringer’s injection to a dilution of at least 1:40 and used within 6 hours or to a dilution of 1:50 and used within 24 hours …

How do you give diazepam IM?

Intramuscular: Diazepam Injection, USP should be injected deeply into the muscle. Intravenous use: (See WARNINGS, particularly for use in children.) The solution should be injected slowly, taking at least one minute for each 5 mg (1 mL) given. Do not use small veins, such as those on the dorsum of the hand or wrist.

Why is diazepam given slowly?

Patients with a benzodiazepine hypersensitivity to other benzodiazepines may experience a cross-sensitivity to diazepam. Intravenous diazepam should be injected slowly to reduce the possibility of local reactions; avoid intraarterial administration or extravasation.

What happens when diazepam is diluted?

Dilutions lower than 1:20 (5 mg in 20 ml) resulted in immediate visible precipitates in all four diluents. The 1:20 dilution was compatible with all four diluents and maintained acceptable potency for four hours, whereas at 1:40 dilution (5 mg in 40 ml) diazepam was stable for at least 6-8 hours in the same diluents.

How long does diazepam peak?

The half-life of diazepam in general is 30–56 hours. Peak plasma levels occur between 30 and 90 minutes after oral administration and between 30 and 60 minutes after intramuscular administration; after rectal administration, peak plasma levels occur after 10 to 45 minutes.

Can diazepam be diluted?

In general, diazepam should not be mixed or diluted with other drugs or added to IV fluids. However, if IV infusion is required, diazepam in doses up to 20mg can be added to at least 250ml of 5% dextrose or normal saline. Do not use any solution that is cloudy.

How do you prepare diazepam injections?

Dissolve the diazepam and benzoic acid in the solution. Slowly add Sterile Water for Injection to a volume of 75 to 80 mL. Add the sodium benzoate and mix until dissolved; then add the sodium hydroxide solution or hydrochloric acid to adjust the pH to the range of 6.2 to 6.9.

Can diazepam be mixed with normal saline?