How do you calculate serum cystatin C?

How do you calculate serum cystatin C?

The serum cystatin C was determined by an immunonephelometric method and our own cystatin C formula (GFR = 90.63 x cystatin C-1.192) for estimation of GFR was developed. GFR was measured using 51CrEDTA clearance, and the correlation, accuracy, bias and precision were determined.

How is serum clearance calculated?

Est. Creatinine Clearance = [[140 – age(yr)]*weight(kg)]/[72*serum Cr(mg/dL)] (multiply by 0.85 for women). The results you receive from this tool are for informational purposes only and should not be the basis of your medical decision making.

What is serum cystatin C?

Serum cystatin C is a non-glycosylated, 13.3-kDa protein belonging to cystatin protease inhibitors. It has shown promise as a replacement for serum creatinine in estimation of GFR. [4,5] After glomerular filtration, it is fully catabolized in the proximal renal tubule and is not returned to blood.

What is the Schwartz formula?

Original Schwartz Equations: eGFR = k x (height in cm) ÷ serum Cr. k = 0.33 in preemie infants. k = 0.45 in term infants to 1 year of age.

How do you interpret cystatin C?

Cystatin C is a protein that is produced by the cells in your body. When kidneys are working well, they keep the level of cystatin C in your blood just right. If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well.

Why is cystatin C better than creatinine?

Like serum creatinine, cystatin C concentrations were much more stable in individuals without renal disease than was GFR measured by creatinine clearance [5]. A possible advantage of cystatin C with minor glomerular damage is that, being a large molecule, blood levels of cystatin C might rise sooner than creatinine.

What is a good cystatin C level?

The normal range of cystatin C is around 0.62 – 1.15 mg/L. Values can vary between laboratories. Generally, higher cystatin C levels point to poor kidney function [7].

What is a high cystatin C level?

If you have an abnormally high concentration of cystatin C in your blood, it may mean you may have a kidney condition, such as chronic kidney disease. Higher levels of cystatin C may also be caused by diabetes, cancer, HIV, hyperthyroidism, or hypothyroidism.

How do you interpret Cystatin C?

Is cystatin C more accurate than creatinine?

The maximum diagnostic accuracy of serum cystatin C (90%) was significantly better than those of serum creatinine (77%) and Cockcroft and Gault estimated GFR (85%) in discriminating between type 2 diabetic patients with normal GFR (>80 mL/min per 1.73 m2) and those with reduced GFR (<80 mL/min/1.73 m2).