How do you administer Prothrombinex?

1. Prothrombinex®-VF should be given as an infusion or slow IV push at 3 mL/min (180mL/hour) or 7 minutes a vial.
2. IV infusion should be completed within 3 hours of reconstituting bottle.

How do you administer a Beriplex?

Beriplex is presented as powder and solvent. It is a white or slightly coloured powder or friable solid. The made up solution is to be given by injection into a vein. Beriplex is made from human plasma (this is the liquid part of the blood) and it contains the human coagulation factors II, VII, IX and X.

How do I administer Octaplex?

Octaplex should be administered intravenously. The infusion should start at a speed of 1ml per minute, followed by 2-3 ml per minute using an aseptic technique. The single dose should not exceed 3000 units for Factor IX (120mls of Octaplex). Octaplex is a virally inactivated product.

How is prothrombin complex administered?

Diluted prothrombin complex concentrate should be administered by IV infusion at a rate of 0.12 mL/kg/min (about 3 units/kg/min) up to a maximum rate of 8.4 mL/min (about 210 units/min).

How long does Prothrombinex take to work?

Prothrombinex-VF is able to completely reverse an excessive INR within 15 minutes, but the infused clotting factors have half-lives similar to endogenous clotting factors. Therefore, vitamin K1 5–10 mg should be given intravenously with the PCC to sustain the reversal effect.

What is Prothrombinex used for?

Prothrombinex®-VF is indicated in: Treatment and perioperative prophylaxis of bleeding in acquired deficiency of prothrombin complex factors, such as deficiency caused by treatment with vitamin K antagonists, or in case of overdose of vitamin K antagonists, when rapid correction of the deficiency is required.

How quickly does Beriplex work?

The simultaneous administration of vitamin K should be considered in patients receiving Beriplex for urgent reversal of vitamin K antagonists since vitamin K usually takes effect within 4-6 hours.

How long does Beriplex last for?

Once reconstituted, Beriplex is stable for 24 hours at room temperature (maximum 25°C); however, from a microbiological point of view, the product should be used immediately.

How long does it take for Octaplex to work?

The correction of the vitamin K antagonist induced impairment of haemostasis persists for approximately 6-8 hours. However, the effects of vitamin K, if administered simultaneously, are usually achieved within 4-6 hours.

How do you dilute Octaplex?

Making up the Octaplex and infusion rates 500 iu of Octaplex is dissolved in 20 mls of sterile water. The solution will have a bluish tinge, this is normal.

How long does Prothrombinex last?

It must, therefore, be used immediately after reconstitution. Store at 2°C to 8°C (Refrigerate. Do not freeze). Prothrombinex®-VF can be stored below 25°C for a single period of 6 months.

When do you give prothrombin complex?

In patients with acquired deficiency of the vitamin K-dependent coagulation factors (e.g. as induced by treatment of vitamin K antagonists), Beriplex should only be used when rapid correction of the prothrombin complex levels is necessary, such as major bleedings or emergency surgery.

What is in prothrombinex ®-VF?

Prothrombinex ® -VF is supplied as a 500 IU vial containing 500 IU of factor IX, 500 IU of factor II and 500 IU of factor X. Each single pack contains one vial of product, one 20 mL vial of Water for Injections and one Mix2Vial filter transfer set. Compatibility is not relevant for manufactured (fractionated) plasma product transfusion

What should I do with unused prothrombinex-VF?

Prothrombinex-VF is packaged in latex free materials. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

What is the recommended INR level for prothrombinex ®-VF?

Prothrombinex ® -VF for reversal of warfarin: 25-50 IU/kg in the following situations: INR is ≥ 1.5 with life threatening (critical organ) bleeding

Does prothrombinex-VF interact with other medications or foods?

Prothrombinex-VF is formulated with heparin sodium and antithrombin III. Therefore, the results of coagulation tests should be interpreted with care. The interaction of Prothrombinex-VF with other medicines has not been established in specific studies.