Is endemic syphilis curable?

One oral dose of azithromycin (30 mg/kg, not to exceed 2 g) is now recommended as equivalent to benzathine benzylpenicillin. Because of the ease of administration and low cost, it is now considered the drug of first choice. Yaws, pinta, and endemic syphilis may also be treated with benzathine penicillin G.

What disease is caused by Treponema pallidum?

Syphilis is a sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. It is transmitted from person to person via direct contact with a syphilitic sore, known as a chancre.

Is syphilis French disease?

The first written records of an outbreak of syphilis in Europe occurred in 1494 or 1495 in Naples, Italy, during a French invasion (Italian War of 1494–98). Since it was claimed to have been spread by French troops, it was initially called the “French disease” by the people of Naples.

What is the syphilis gene?

An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Penicillin G and Emtricitabine have been mentioned in the context of this disorder.

Is endemic syphilis an STD?

Bejel, or endemic syphilis, is a chronic skin and tissue disease caused by infection by the endemicum subspecies of the spirochete Treponema pallidum….

What are the symptoms of endemic syphilis?

Also known as endemic syphilis, bejel is characterized by lesions of the skin and bones that begin in the mouth and progress in gradual stages. The late stages are the most severe. Bejel is very common in dry, hot climates especially in the countries of the eastern Mediterranean region and in Saharan West Africa.

What causes endemic syphilis?

Endemic syphilis is caused by T pallidum subsp endemicum. Endemic syphilis is transmitted through direct or indirect skin-to-skin or mouth-to-mouth contact with the infected lesion. It occurs predominantly in children aged 2-15 years.

Can poor hygiene cause syphilis?

BACKGROUND. CAUSATIVE AGENTS. Syphilis is a chronic infectious disease caused by the spirochaete Treponema pallidum. Syphilis is usually transmitted by sexual contact or from mother to infant, although endemic syphilis is transmitted by non-sexual contact in communities living under poor hygiene conditions.

How do you prevent bejel?

Widespread use of penicillin has been responsible for reducing the number of existing cases, but the only way to eliminate bejel is by improving living and sanitation conditions and through continuing health education.