Which of the following is renin inhibitors?

Aliskiren, an orally active non-peptide renin inhibitor, was the first drug in its class on the market. It is used to treat hypertension as monotherapy or in combination with other antihypertensive agents.

Is ACE a Exopeptidase?

ACE acts as an exopeptidase to cleave dipeptides from the free C-termini of two typical substrates, Ang I and bradykinin.

Which enzyme is an Exopeptidase?

An exopeptidase is any peptidase that catalyzes the cleavage of the terminal (or the penultimate) peptide bond; the process releases a single amino acid or dipeptide from the peptide chain.

What drugs are RAAS inhibitors?

Types of RAAS inhibitors

• Drug names: enalapril, lisinopril, ramipril, captopril, benazepril.
• Indications. Arterial hypertension. Diabetes mellitus (type I and type II) with ; Nephroprotective indications, such as: Arterial hypertension. Microalbuminuria and proteinuria (especially ≥ 300 mg/g) Coronary heart disease.

Is aliskiren a direct renin inhibitor?

Renin controls the rate-limiting step in the RAAS cascade and hence is the optimal target for RAAS suppression. Aliskiren is the first direct renin inhibitor (DRI) to be approved by the U.S. Food and Drug Administration and the European Medicines Agency for treating hypertension.

Is protease an Exopeptidase?

Proteases (peptidases) are enzymes that hydrolyze peptide bonds in proteins. Exopeptidases cleave a terminal amino acid residue at the end of a polypeptide; endopeptidases cleave internal peptide bonds. Hooper (2002) provides a useful introduction to the general properties of proteases.

Is chymotrypsin an Exopeptidase?

The exocrine pancreas secretes three endopeptidases (trypsin, chymotrypsin, and elastase) and two exopeptidases (carboxypeptidase A and carboxypeptidase B) in inactive forms.

Is Amlodipine a RAAS inhibitor?

Aldosterone secretion, abnormally elevated in heart failure and hypertension, can be blunted with angiotensin-converting enzyme inhibitors. Amlodipine, used to treat hypertension and heart failure, was hypothesized to activate the renin-angiotensin-aldosterone system (RAAS).

What is an example of an endopeptidase?

Pepsin, Chymotrypsin, Thermolysin and Trypsin are examples for endopeptidases. What is Exopeptidase? Exopeptidases are the enzymes that catalyze the breaking of peptide bonds at the terminals and removing single amino acids from the protein molecules.

Does cathepsin S have exopeptidase activity?

Cathepsin S is an endopeptidase with no detected exopeptidase activity. Although the substrate specificity of cathepsins S, B, and L is very similar, the enzymes show significant differences in their S2 subsite specificity.

What is the function of exopeptidase?

Exopeptidases are the enzymes that catalyze the breaking of peptide bonds at the terminals and removing single amino acids from the protein molecules. Furthermore, carboxypeptidase and aminopeptidase are two types of exopeptidases.

How to determine exopeptidase activity of microorganisms used for protein hydrolysis?

The exopeptidase activity of microorganisms used for protein hydrolysis is usually determined with whole cells or cell-free extract of the microorganisms (Sanz & Toldrá, 1997) through the use of labeled substrates.