What is the significance of teardrop cells?

The presence of teardrop-shaped cells may indicate: Myelofibrosis. Severe iron deficiency. Thalassemia major.

Why do dacrocytes form?

Teardrop cells (Dacrocytes) are thought to form as a result of the removal of an inclusion from the cell as it moves through the spleen. This process is referred to as pitting.

What is the purpose of reporting red cell morphology?

The purpose of a red cell morphology report is to convey to the physician the abnormal findings in a legible, comprehensible, and concise manner that will enable judgment on the clinical significance of the abnormalities.

What do dacrocytes mean?

A dacrocyte (or dacryocyte) is a type of poikilocyte that is shaped like a teardrop (a “teardrop cell”). A marked increase of dacrocytes is known as dacrocytosis.

Is myeloma the same as myelofibrosis?

Myelofibrosis may occur as a secondary characteristic of another bone marrow disorder such as polycythemia vera, multiple myeloma, certain metabolic disorders, and/or chronic myeloid leukemia.

What are the symptoms of myelofibrosis?

Symptoms

• Feeling tired, weak or short of breath, usually because of anemia.
• Pain or fullness below your ribs on the left side, due to an enlarged spleen.
• Easy bruising.
• Easy bleeding.
• Excessive sweating during sleep (night sweats)
• Fever.
• Bone pain.

What is the role of transferrin in the cycle shown above?

What is the role of transferrin in the cycle shown above? It transports iron ions in the plasma.

What does a positive poikilocytosis mean?

The term poikilocytosis refers to a condition where 10% or more of the red blood cells are abnormally shaped due to other medical conditions. These cells may have point-like projections or may include shapes that are flat, elongated, teardrop, or in the shape of a sickle or crescent.

What causes dacrocytes in the bone marrow?

•Teardrop cells (dacrocytes) are frequently associated with infiltration of the bone marrow by fibrosis, granulomatous inflammation, or hematopoietic or metastatic neoplasms. They can also be seen in patients with splenic abnormalities, vitamin B12 deficiency, and some other forms of anemia.

What is the pathophysiology of teardrop cells (dacrocytes)?

•Teardrop cells (dacrocytes) are frequently associated with infiltration of the bone marrow by fibrosis, granulomatous inflammation, or hematopoietic or metastatic neoplasms.

What are dacryocytes in peripheral blood smears?

Background: Dacryocytes are teardrop-shaped erythrocytes which are most frequently observed in peripheral blood smears of patients with primary or secondary myelofibrosis as well as malignant infiltrative disorders of the bone marrow.

Are dacryocytes a common morphologic feature of autoimmune and microangiopathic hemolytic anaemia?

Dacryocytes are a common morphologic feature of autoimmune and microangiopathic haemolytic anaemia The results of this study indicate that dacryocytes are commonly apparent in blood smears of patients with AIHA and MAHA. Knowledge of this frequent feature may be beneficial in clinical routine diagnosis.